A sound-based biofabrication platform for rapid orchestration of multicellular living systems

Host Society:  AO Research Institute Davos

Organiser:
Tiziano Serra, AO Research Institute Davos

Abstract:
Spatial patterns of cells, organoids, or inorganic particles can be forced on demand using acoustic standing waves, such as the Faraday waves. We call this method Sound Induced Morphogenesis (SIM). SIM allows tuning of pattern parameters under contactless, fast and mild culture conditions, for intimate and controlled cell-cell communication, anisotropic organization, and coordination towards directing morphogenesis and achieving tissue functionality.

Adaptations of innovations and new technologies in spinal deformity treatment

Host Society:  Japanese Orthopaedic Association

Organiser:
Masashi Miyazaki, MD, PhD
Clinical Associate Professor, Department of Orthopaedic Surgery, Faculty of Medicine, Oita University

Abstract:
Profound innovation and advancement in operative techniques, supportive technologies and pharmacological treatments have impacted surgical treatment of spinal deformity surgery. In the first part of the workshop, merits and concerns in application of these technologies will be discussed on adolescent idiopathic scoliosis, adult spinal deformity including deformity arising from osteoporotic vertebral fractures. Augmented and mixed reality has taken fame in the operative theaters in various surgeries including spinal deformity. In the second part of the workshop, its application and perspectives on how it can impact surgical management of spinal deformity surgery will be discussed. Additionally, artificial intelligence will play an even greater role in various fields of spine care such as clinical decision making, imaging diagnosis, prognosis prediction, surgical support and even education for young doctors. In the third of this workshop, how we should coexist and co-prosper with this technology will be discussed.

Talks:
Innovations and New Technologies in Spinal Deformity Treatment
Speaker: Masashi Miyazaki, MD, PhD; Department of Orthopaedic Surgery, Faculty of Medicine, Oita University

Augmented and Mixed Reality in Spinal Surgery: A Real World Experience
Speaker: Daisuke Sakai, MD, PhD; Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine

How will artificial intelligence change clinical practice and education for spine surgeon?
Speaker: Takashi Kaito, MD, PhD;  Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine

Additive manufacturing of orthopedic biomaterials – from lab to application

Host Society:  European Orthopaedic Research Society

Chairs:
Nicola Baldini (Bologna, Italy), Holger Jahr (Aachen, Germany)

Abstract
Additive manufacturing, or 3D printing, provides unparalleled opportunities to realize the challenging requirements of producing personalized and even bone-mimetic implants. This session will give you the latest insights on instruments and materials currently being used for 3D printed customized medical devices for total knee arthroplasties from an industrial point of view. Additive manufactured solutions and perspectives based on clinically relevant needs will be addressed. Furthermore, novel approaches towards mimicking biological gradients in the design of 3D printed scaffolds to regenerate skeletal pathologies in the future will be presented. Due to the high economical and personal impact of surgical complications resulting from implant infections, we will further specifically address current trends in combining additive manufacturing and nanoscale materials to control cells fate and manage implant-related bone infections. Bone substitutes should not only fight infections, but also facilitate osseointegration. To this end, metallic materials are promising to tackle this challenge and a special attention will thus be devoted to metal-based biomaterials and nanomaterials. We will discuss the impact of topological design of future 3D printed metallic implants and associated technological challenges thereof. Finally, direct printing of porous absorbable metal implants for the treatment of large bone defects will be presented as a solution providing mechanical support in load-bearing anatomical regions, facilitating osseointegration, and ultimately eliminating the risk of implant-associated osteitis after their job is done. New strategies to better predict the translational potential of these antibacterial and osteogenic medical devices will be briefly addressed as well.

Talks:
3D printing in Total Knee Arthroplasty – Implants, Instruments, complex customized devices and related materials
Speaker: Berna Richter (Aesculap AG, Germany)

Towards mimicking biological gradients in 3D scaffolds design for skeletal regeneration
Speaker: Lorenzo Moroni (MERLN, Netherlands)

Combining additive manufacturing and nanoscale materials to control cells fate and discourage infection
Speaker: Gabriela Graziani (Bologna, Italy)

Translational potential of novel 3D printed porous absorbable metallic medical devices
Speaker: Holger Jahr (RWTH Aachen, Germany)

Application of Advanced Technologies in Bone and Cartilage Research

Host Society: International Chinese Musculoskeletal Research Society (ICMRS)

Organisers:
Professor Minghao Zheng M.D., Ph.D.
Professor of Orthopaedic Research
Medical School of The University of Western Australia

Professor Wentian Yang M.D., Ph.D.
Associate Professor of Orthopaedics and Medicine
Brown University Alpert Medical School
Providence, RI 02903, USA

Abstract:
This workshop focuses on several technological advances that have been applied for bone and cartilage research during the past few years. Professor Zheng's research primarily centers on translational medicine and bioengineering of bone, cartilage, and tendon. He developed the first cellular engineering product for cartilage repair MACI approved by the FDA and Celgro collagen technology platform for tendon, nerve, cartilage, and bone regeneration. Dr. Zheng has published over 200 papers and holds 30 patents. He has over 9000 citations with H index of 54. In this workshop, Dr. Zheng will discuss the real-time confocal assessment of osteocytes. Dr. Yang studies the role of protein tyrosine phosphatases (PTPs) in skeletal development and diseases, particularly the ubiquitously expressed PTP SHP2 with cellular context-specific effects. Somatic SHP2 deletion in chondroid and bone cells causes a cartilage tumor syndrome metachondromatosis and defective ossification, respectively, implicating a crucial role for SHP2 in the skeleton. How SHP2 functions in skeletal cells, however, remains incompletely understood. In this Workshop, Dr. Yang will discuss the use of a series of genetically modified mice in combination with cutting-edge technologies, including live cell lineage tracing, phosphoproteomics, scRNA-seq, RNAscope®, and biochemical assays to dissect the role of SHP2  at the cellular and molecular levels in the skeletal tissue.   Lastly, Dr. Xia will introduce Colour Electron Microscopy and its application in Metallosis studies. Metallosis, also termed adverse reactions to metal debris, is a combination of aseptic inflammation, local tissue necrosis, toxic metal ions increasing in tissue and blood, and fibrosis secondary to metallic corrosion and release of wear debris. Consequently, it results in loosening or failure of the implanted devise. Metal allergy can partially explain some clinical cases, but the mechanism is still not fully understood. Dr. Xia will discuss several important findings of metallosis from his team using color electron microscopy in combination with nanostructure and element analysis.

Talks:
Reali-time Confocal Assessment of Osteocytes
Professor Minghao Zheng M.D., Ph.D.
Professor of Orthopaedic Research
Medical School of The University of Western Australia

New Technology-based Novel Insights into PTPN11 Regulation of Skeletal Development and Diseases
Professor Wentian Yang M.D., Ph.D.
Associate Professor of Orthopaedics and Medicine
Brown University Alpert Medical School
Providence, RI 02903, USA

Colour Electron Microscopy: See Through Metallosis
Zhidao Xiao, M.D., Ph.D.
Senior Lecturer of Regenerative Medicine
Centre for Nanohealth, Swansea University Medical School,
Singleton Park, Swansea SA2 8PP, United Kingdom

Artificial Intelligence in orthopaedics: The good, the bad and the ugly

Host Societies: Australia and New Zealand Orthopaedic Research Society

Chairs:
A/Prof David Ackland and Dr Damith Senanayake

Abstract:
Artificial intelligence (AI) is being increasingly incorporated into main-stream orthopaedics, facilitating applications that include image diagnostics, human motion classification, surgical planning, clinical decision making, and medical device development. This workshop will present recent advances and best practices in AI techniques and other forms of computational automation that are supporting the orthopaedics industry, and the challenges that must be overcome in the adoption of this emerging technology

Talks:
Real-time data processing: IMU data to joint angle conversion using deep neural networks
Speaker: David Ackland 

Image-based feature extraction and classification: Detecting fracture risk in fallers using DEXA images and deep-learning
Speaker: Damith Senanayake 

Statistical shape modelling for automation: Applications in clinical orthopaedics
Speaker: Dale Robinson 

Use of deep learning tools for gait analysis
Speaker: Dominic Thewlis 

Bone infection: a clinical priority for clinicians and scientists

Host Society:  Orthopedic Research Society

Chairs:
Prof. E.M. Schwarz
Prof. R.G. Richards

Abstract: 

Talks:
Emergence of virulent pathogens revealed by phylogenomic studies from a registry for bone infection.
Speaker: Stephen L Kates MD, Virginia Commonwealth University. 

Development of a passive immunization for Staphylococcus aureus Osteomyelitis
Speaker: Prof. E.M. Schwarz

Deciphering immune responses in humanized mice with S. aureus bone infection
Speaker: Gowrishankar Muthukrishnan PhD.

Antibiotic therapy for bone infection: impact on gut microbiome and implications for bone health

Cartilage regeneration: Concepts and Techniques of improving Chondrogenesis.

Host Society:  ASEAN Orthopaedic Research Society

Chair:  Joyce Koh

Abstract:
Our understanding and practices in cartilage regeneration have undergone paradigm shifts over the years.  Conceptually, we know that cellular processes and mechanical stimuli interact to determine clinical outcomes. Practices continue to evolve as recent clinical trials fine-tune our current knowledge.

This interactive workshop showcases the collaborative efforts of member countries of the Asean (AP) Orthopaedic Research Society as we share our laboratory experiences in mechanical signalling pathways, and role of various cellular components such as mesenchymal stem cells, secretome, somatotrophine and exosomes in regulating Cartilage regeneration.

This is followed by a discussion of current techniques of cartilage implantation and a sharing of clinical outcomes from recent collaborative trials.

Concept Talks:
Signaling Pathways in Cartilage Repair and Regeneration            
Speaker: Tunku Kamarul Zaman Director of the Universiti Sains Malaysia (USM), Advanced Medical and Dental Institute (IPPT), Malaysia
Role of MSC, secretome, somatotrophine and exosomes in regulating Cartilage regeneration    
Speaker: Ismail Hadisoebroto Dilogo; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunksumo Central National Hospital, Jakarta, Indonesia

Technique Talks:
Chondrocyte induced cartilage regeneration-ACI: How I do it.   
Speaker: Deepak Goyal, Saumya Arthroscopy & Sports Knee Clinic, Ahmedabad, India; President , Asian Cartilage Repair Society India
Exosomes in OA of the knee- early outcomes of a multicenter trial
Speaker: Sureshan Sivananthan Department of Orthopaedic Surgery, ALTY Hospital, Menara HSC, 187 Jalan Ampang, Kuala Lumpur, Malaysia, Malaysia/USA

Digitalization in orthopaedics and traumatology – global data and patient outcomes

Host Societies: European Orthopaedic Research Society/ AO Research

Organiser:
Prof Boyko Gueorguiev, AO Research Institute Davos, Switzerland

Abstract:
Implementation of digital technologies has been enhancing the translational research and development in focusing towards innovative clinical solutions and applications, and solving existing clinical problems.  Aim and scope of this workshop is dissemination of novel approaches in orthopaedics and traumatology to promote excellence in patient care and outcomes in trauma and musculoskeletal disorders, to focus on the importance of the chain training-indication-improvement-therapy-outcome-monitoring-rehabilitation, and to contribute to enhancing today's postoperative care.

Speakers:
Dr. Roland Herzog, AO Innovation Translation Center, Switzerland
Dr. Markus Windolf, AO Research Institute Davos, Switzerland
Dr. Alexander Joeris, AO Innovation Translation Center, Switzerland

How does joint loading influence pain and degeneration in osteoarthritis?  

Host Society:  British Orthopaedic Research Society

Chair:
Prof Ilse Jonkes, KU Leuven, Belgium

Talks:
What does epidemiology and genetics tell us about mechanical risk of OA?
Speaker: Mark Wilkinson, Sheffield, UK (orthopaedic surgeon)

How does mechanical loading alter biological signals in the joint?
Speaker: Deborah Mason, Cardiff, UK (bioscientist)

Personalised HTO interventions for early knee OA, can mechanical re-alignment be a cure?
Speaker: Richie Gill, Bath UK, (engineer)

Finite element modelling in orthopaedic research.

Host Society: British Orthopaedic Research Society/ AO Research 

Chair:
Andrew Phillips

Abstract:

Talks:
What can finite element modelling tell us in orthopaedic research? 
Speakers: Ruth Wilcox/Gavin Day (University of Leeds)

FEA in the development of TOKA (a patient specific surgical treatment for knee osteoarthritis)  
Speaker: Richie Gill (University of Bath)

FEA for understanding bone remodelling   
Speaker: Gordon Blunn, University of Portsmouth

FEA in multiscale modelling of bone
Speaker: Marta Pena Fernandez (Heriot Watt University)

Imaging innovation for foot and ankle disorders 

Host Society:  Japanese Orthopaedic Association

Organisers:
Yasuhito Tanaka, MD, PhD
Professor, Department of Orthopaedic Surgery, Nara Medical University

Hisateru Niki, MD, PhD
Professor, Department of Orthopaedic Surgery, St. Marianna University School of Medicine

Abstract:
Since the foot and ankle are composed of many bones and are loaded parts, it may be difficult to evaluate the pathology of the disorder. However, new modalities have recently emerged in the visualization of foot and ankle evaluations. In this workshop, four presenters will introduce the application of ultrasound examination for the foot and ankle, T1ρ mapping of osteoarthritis of the ankle, 3D MRI of lateral ankle ligament injuries, and weight-bearing CT of hallux valgus, discuss recent advances and applications in this area. Imaging innovations for the foot and ankle are expected to contribute to advances in diagnosis and treatment of disorders. 

Talks:
Ultrasound evaluation of ankle ligament
Speaker: Hiroaki Kurokawa, MD, PhD; Department of Orthopaedic Surgery, Nara Medical University

T1ρ mapping of ankle cartilage
Speaker: Naoki Haraguchi, MD, PhD, Department of Orthopaedic Surgery
St. Marianna University Yokohama Seibu Hospital

3D MRI of lateral ankle ligament injuries
Speaker: Atsushi Teramoto, MD, PhD; Department of Orthopaedic Surgery, School of Medicine, Sapporo Medical University

Weight-bearing CT of hallux valgus
Speaker: Tadashi Kimura, MD, PhD; Department of Orthopaedic Surgery, The Jikei University School of Medicine

Leadership and representation in orthopaedic and musculoskeletal research: challenging the status quo.  

Host society: European Orthopaedic Research Society

Chairs:
Associate Prof. Federica Francesca Masieri, PhD; University of Suffolk
Prof. Elizabeth Rosado Balmayor, PhD; RWTH Aachen University

This symposium aims at presenting and discussing inspiring, high-quality contributions brought by a diverse body of eminent scientists in orthopaedic and musculoskeletal research. We want to provide a comprehensive discussion platform to emphasise the progress accomplished and reflect on the work still to be done in a science area often perceived as one of the least open to diversity and inclusion. Relevant topics such as female representation in science, gender equality, and the impact of females on scientific work will be discussed. We wish also to provide an allied platform for the LGBTQIA+ community and their intersectionality with women representation. We recognise that gender inequalities, unconscious bias, and associated patterns are transversal instances, often hindering the opportunity for fair representation in academia, industry, and the wider society. These disparities have been unfortunately further enhanced by the ongoing COVID-19 pandemic.
We plan to have 1 invited speaker and 2 podium presentations from submitted abstracts (if applicable).

In addition, after the talks, a round table will be organized with the keynote, speakers, and chairs to stimulate an open discussion on all the above mentioned subjects. The audience will be stimulated to interact and participate in an open discussion. Opinions beyond what will be presented during the talks will have a podium for discussion on this round table.

Talks:

Moving the Needle: Impactful Research in Orthopaedics

Host society:  Canadian Orthopedic Research Society

Chairs:
John Antoniou, MD, PhD
Joy Macdermid (CORS Executive)

Abstract:
We aim to showcase important musculoskeletal research from Canadian centres that has influenced clinical practice in orthopaedics. The purpose is to highlight the importance of the collaboration between scientists and clinicians in our field. More specifically we want to address the issues of hip instability. In the recent years, new information has emerged regarding the pathology of the hip instability, however a better understanding of the etiology and the pathology of this disease processes in the hip are essential to provide better treatments. Pathologies like femoroacetalular impingement syndrome, hip dysplasia, and other hip-related conditions can lead to hip instability due to soft tissues laxity and muscle imbalance causing cartilage defects and resulting in osteoarthritis (OA) and total hip arthroplasty (THA). Abnormal spinopelvic mobility may also lead to hip instability, which has a significant effect on the THA outcomes. 

This workshop will provide knowledge on the most recent development in the understanding of the etiology, anatomy and biomechanics, soft tissues imbalance (ligaments and muscles) and the spinopelvic mobility on hip instability.

Talks:
The aetiology and clinical indications of hip instability
Speaker: Paul Beaulé, MD

Anatomical mapping and the role of the capsule to maintain hip stability
Speaker: K.C. Geoffrey Ng, PhD

The importance of muscle-ligament balance in hip instability
Speaker: Mario Lamontagne, PhD

Spine-pelvic mobility and hip instability

New focus areas in osteoarthritis research

Host Societies: Taiwanese Orthopaedic Research Society, European Orthopaedic Research Society

Chairs:
Feng-Sheng Wang (Taiwan)
Holger Jahr (Aachen, Germany)

Summary
Osteoarthritis (OA) is the most frequent, and highly heterogeneous, form of arthritis. While affecting the whole joint, a progressive loss of articular cartilage is still a hallmark. Better biomarkers would allow for an early detection of this disease, when its progression may still be altered by therapeutic intervention and a deeper understanding of mechanisms causing OA is essential for developing novel disease-modifying therapeutics. Ideally tailored to the diversity of clinical phenotypes, early identification of OA subtypes may transform clinical treatment efficiency. Biochemical and imaging biomarkers are important diagnostic and research tools assisting with this challenge. As a number of mechanisms may be shared by several phenotypes, using artificial intelligence during non-destructive quantitative optical characterization of early changes in the cartilage holds tremendous potential to this end. Microenvironmental factors and their differences between different subtypes may further assist in decision making of improved early pharmacological intervention. The gut microbiome is responsible for a series of metabolic and immunological functions, potentially elucidating the heterogeneity of OA phenotypes. Hinting at human relevance, a couple of recent studies have suggested that patients diagnosed with OA possess a quantifiable dysbiosis in the gut microbiome. Aiming at shedding light on this “gut-joint axis”, the interactions between gut microbiota and factors relevant to OA progression, the role of innate immunity, and probiotics and other potentially promising manipulations of the microbiome in the management of OA will be presented. Moreover, mitochondrial energetics in chondrocytes, articular cartilage integrity, microbiota-derived metabolites as potential biomarkers related to inflammation, their potential to predict OA progression and monitoring therapeutic intervention efficacy will be discussed.

Talks:
Tissue-dependent biomarkers and microenvironmental factors in osteoarthritis
Speaker: Holger Jahr, PhD, Dept. Orthopedic Surgery, MUMC+/Dept. Anatomy, RWTH Aachen

Introducing a future-oriented, AI-supported, non-destructive quantitative optical biopsy for early disease detection
Speaker: Bernd Rolauffs, PhD/MD, Dept. Orthopedics and Trauma Surgery, Freiburg

Gut microbiota-derived metabolites regulate chondrocyte metabolism and obesity-induced osteoarthritis
Speaker: Feng-Sheng Wang, MS, PhD, Kaohsiung Chang Gung Memorial Hospital, Taiwan

The role of gut ecosystem in the development of osteoarthritis: friend or foe
Speaker: Wei-Shiung Lian, PhD, Kaohsiung Chang Gung Memorial Hospital, Taiwan

Prevention of Post Traumatic Osteoarthritis: research needs and barriers?  

Host Society:  British Orthopaedic Research Society

Chairs:
Dr Fiona Watt
Professor Deborah Mason  

Abstract:
This workshop is intended for patients, clinicians (surgeons, physiotherapists, vets, emergency room), scientists, and engineers with an interest in therapies for preventing PTOA. 

This workshop follows on from the report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury (Watt et al. 2019, Osteoarthritis and Cartilage, Volume 27, Issue 1, 23 – 33), which addressed key overarching considerations and highlighted the need for improved understanding of PTOA pathogenesis and appropriate timing of interventions, their feasibility and acceptability. The considerations highlighted in this paper were to be reviewed and addressed periodically and this workshop will contribute directly to this process.
Prior to the workshop a survey will be conducted to assess attendees perceptions of the range, efficacy and limitations of current treatments that might prevent OA after knee injury, as well as the need for new treatments seeking to prevent PTOA, and feasibility and acceptability of different potential treatments. The workshop will present the survey questions and results in the context of these previous research recommendations, then focus on discussions of the following specific research recommendation areas highlighted, particularly considering pharmacologic interventions for prevention of PTOA after knee injury: 
•             ‘Experimental medicine' studies in humans should be used to define the likely best delivery of an intervention, its optimal time-window and initial pharmacokinetics, to support future clinical trials 
•             Patient and public involvement should be sought, particularly around areas of assessing risk of disease, risk of harm, risk of overtreatment and acceptability of different types of proposed interventions 
Feasibility studies are encouraged to address questions specific to an intervention, acceptability to patients, and refine best outcomes.  

Attendees will be assigned to small, inter-disciplinary, breakout groups with facilitators and rapporteurs to address key questions in each of the areas above. All groups will report their findings at the end of the workshop and final opinions of all workshop attendees recorded using a survey within the workshop. The findings from this workshop will feed into ongoing working group activity in this area. 

Research: Pearls for Success for Surgeons

Host Society:  Orthopedic Research Society

Moderator:

Theodore Miclau, MD

Talks:
Introduction:  Theodore Miclau, MD

Characteristics of the successful surgeon scientist: Observations over the Decades
Speaker: Geoff Richards, PhD

Being Productive as a Clinical Researcher with a Busy Practice                 
Speaker: Michael McKee, MD

Balancing Growth of a Basic Research Program With Clinically Activity                     Speaker: Emil Schemitsch, MD

Developing Collaborative Teams with Surgical Colleagues
Speaker: Chelsea Bahney, PhD

Balancing Early Career Demands: Is There Enough Time for Everything?
Speaker: Prism Schneider, MbD

Panel Discussion/Questions

Smart Technology in fracture treatment – current trends and future directions

Host Society:  AO SDSTF

Session Chairs:
Dr. Sureshan Sivananthan, MD, MS, FRCS - Alty Orthopaedic Hospital, Kuala Lumpur, Malaysia
Dr. Bernd Grimm, PhD – Luxembourg Institute of Health, Luxembourg

Talks:
What’s in the literature? – A systematic review of wearable technology in trauma surgery
Speaker: Dr. Meir Marmor, MD - OTI at Zuckerberg San Francisco General, San Francisco, USA

What is out there? Wearable assisted outcome assessment – Results of an AO Survey and own experiences at a level-1 trauma center
Speaker: PD Dr. Benedikt J Braun, BG Hospital, University Tuebingen, Germany

Taking movement analysis out of the lab into clinical routine with with markerless and monocular 3D video capture.
Speaker: Dr. Bernd Grimm, PhD – Luxembourg Institute of Health, Luxembourg

Remote Fracture Treatment with the DaVinci System in Pelvis and Acetabular Surgery
Speaker: PD Dr. Steven C Herath, MD – BG Hospital, University Tuebingen, Germany

Tendinopathy - a relevant clinical problem and a growing research field

Host Society: Musculoskeletal Regeneration Network (MR-NET) of the German Society of Orthopaedics and Trauma Surgery (DGOU)

Chairs: 
Prof. Britt Wildemann (Jena)        
Prof. Denitsa Docheva (Wuerzburg)

Abstract:
Tendon pain and dysfunction is frequent in all types of athletes and also in the aging population. "Tendinopathy" describes a broad spectrum of tendon disorders and causes activity-related tendon pain resulting in restricted movement and disability associated with in a high socioeconomic burden. It occurs in various anatomical locations of the body and affects diverse tendons such as the Achilles, patellar, and rotator cuff tendons. Despite the clinical relevance, tendon disorders are less studied compared to other tissues such as bone and cartilage. The presence and contribution of inflammation to the development of tendinopathies has been the subject of controversial discussions for years. Its pathogenic role is now well accepted, although it is far from being adequately understood. Therefore, the knowledge of tendon pathophysiology is still lagging behind and the successful treatment of tendinopathies represents an unsolved orthopaedic challenge. The Musculoskeletal Regeneration Network (MR-NET) of the German Society for Orthopaedics and Trauma Surgery (DGOU) organizes this symposium. The invited speakers, members of the network, will give an overview on the recent clinical and basic research on tendinopathy reporting on novel aspects regarding tendon healing, rotator cuff disease, enthesiopathies and biomaterials.

Talks:
Tendon repair versus regeneration from a clinical point of view
Speaker: Prof. Dr. Richard Stange, University of Munster, Germany

The role of subacromial bursa in rotator cuff tendinopathy: what do we know?
Speaker: Dr. Franka Klatte-Schulz, Charité-Universtätsmedizin Berlin, Germany

Tendon-enthesiopathies: molecular pathogenesis and possible therapies
Speaker: Prof. Dr. Martijn van Griensven, Maastricht University, the Netherlands

Development and assessment of polycaprolactone-based implants for tendon repair
Speaker: Dr. Janin Reifenrath, Medical University, Hannover, Germany

The OATech Network+ and facilitating the next generation of OA researchers: ECR presentations with Q&A

Host: OATech Network

Chair:
Prof Jim Richards (UCLAN)

Talks:
Introduction
Speaker: Prof Cathy Holt (Cardiff) – OATech+ PI – Introduction

Bi-Plane Xray protocols in osteoarthritis
Speaker: Dr David Williams (Cardiff)

Cartilage scanning and analysis in healthy and osteoarthritic mice
Speaker: Lucinda Evans (RVC)

Wearable technology and nociceptive measures in osteoarthritis
Speaker: Dr Rebecca Hamilton (Cardiff)

Smart shoe fabric sensor data to analyse gait assessment
Speaker: Sumetha Kumar (Warwick)

Musculoskeletal modelling for joint prediction in high tibial osteotomy patients
Speaker: Dr Jake Bowd (Cardiff)

Joint, gait and biomechanical analysis in osteoarthritis surgery  

The biology of growth plate and its clinical application

Host Society:  Japanese Orthopaedic Association

Chairs:
Hirotaka Chikuda, MD, PhD
Professor, Department of Orthopaedic Surgery, Gunma University
Graduate School of Medicine

Taku Saito, MD, PhD
Associate Professor, Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo

Abstract:
In recent years, the mechanism of growth control of growth plates has been elucidated, and its clinical application is progressing. In this workshop, we will introduce the latest findings from basic research to clinical application.

Talks:
Endoscopic surgery with dual opposing insertion paths around the physis (ESDOP): long-term results
Speaker:  Takashi Saisu, MD, PhD; Chiba Child & Adult Orthopaedic Clinic

Gene regulatory networks underlying human endochondral bone formation

Tissue regeneration & Repair

Host Society: Korean Orthopaedic Research Society

Chairs:
Professor, Jung Ho Park, MD, PhD, Department of Orthopaedic Surgery, Korea University Ansan Hospital, Ansan, Korea

Professor, Tae-Joon Cho, MD, PhD, Department of Orthopaedic Surgery, Seoul National University Children's Hospital, Seoul, Korea

Abstract:

Talks:
Regeneration therapy for shoulder and elbow tendinopathy
Speaker: Professor, Jun-Gyu Moon; Korea University Guro Hospital, Seoul, Korea

Priming of mesenchymal stem cells for the treatment of osteoarthritis
Speaker: Professor, Hyuk-Soo Han, Seoul National University, College of Medicine, Seoul, Korea

Functional and Anatomical Restoration of Meniscus Using 3D Cell Printing Technique
Speaker: Professor, Joon Ho Wang; Sungkyunkwan University, Samsung Medical Center, Seoul, Korea

Regeneration therapy for diabetic wound repair
Speaker: Professor, Kwang Hwan Park, MD, PhD, Yonsei University, College of Medicine, Seoul, Korea

Translational cell-based therapies in orthopaedics

Host societies: ON Foundation/European Orthopaedic Research Society

Chair:
Gianluca Vadalà (Università Campus Bio-Medico di Roma, Italy)
Norbert Passuti (On Foundation)

Abstract:

 Speakers:
Talks:
Cell therapy for osteoarthritis treatment
Speaker: Frank Barry (National University of Ireland, Galway, Ireland)

Cell therapy for the treatment of low back pain
Speaker: Hans Jörg Meisel (BG Klinkum Bergmannstrost Halle, Germany)

Cell therapy in bone regeneration
Speaker: Enrique Gómez Barrena (Universidad Autónoma de Madrid, Spain)

Transverse Tibial Cortex Transport Surgery:  What is it and Why we need it? 

Host Society:  Chinese Orthopaedic Research Society

Chair:
Prof. Gang Li, MBBS. DPhil (Oxon)
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong

Abstract:
Diabetic foot ulcers (DFU) are severe vascular and neurological complications in the in the lower limbs at later stage of diabetic patients. The incidence DFU was around 6~15%.  Severe DFU usually accompanies such as gangrene, deep and large ulcers and osteomyelitis.  At present, 90% of DFU patients with severity at Wagner III or above end up with amputation.  For those whose ulcers healed through conventional treatments, the recurrence rate is 40% within 1 year, 60% and 65% respectively within 3 and 5-years.  Therefore, new treatments to improve DFU healing and limb salvage rate are in great need. 

Since 2011, clinical scientists in China launched a novel strategy for the treatment of severe DFU (Wagner III and above) by using transverse tibial cortex transport technique (TTT) with proven success.  Following TTT, the wound healing become more responsive and effective.  With a review of a few hundred cases of severe DFU cases treated with TTT in China, the wound healing rate and limb salvage rate was over 95% for Wagner, and 1-year recurrence rate of DFU was less than 9%.

The possible underlying mechanisms for the TTL surgery are: (1) decompress the marrow cavity and promote microcirculation and angiogenesis in the distal limb. (2) systemic factors release to promote stem cells mobilization and wound healing. (3) regulate local inflammation such as macrophages transformation from M1 to M2 phase. (4) other possible mechanisms including improvement in the sympathetic never or lymphatic microcirculation functions.  More studies are still needed to discover the underlying biological mechanisms of TTT treatment for DFU and other peripheral avascular diseases. 

Speaker:

Use of Biologics in ACDF, the AOGO initiative

Host society: AO Spine Knowledge Forum Degenerative

Description:
1 Opening: AOGO the focus and vision: Meisel 6m
2 Use of autograft and allograft in ACDF: Stipe 8m
3 Multilevel fusion and use of hybrid contrast for ACDF: Sathish 8m
4 Use of BMP in ACDF: Gianluca 8m
5 Pre-clinical aspects about biologics: Alini 10m
6 Panel discussions: all 10 mins

Speakers:
Gianluca Vadala
gianluca.vadala@gmail.com
Hans-Jorg Meisel hj.meisel@googlemail.com; meisel@bergmannstrost.com
Stipe Ćorluka stipe@corluka.hr
Mauro Alini mauro.alini@aofoundation.org